The active ingredient in AQUABALM is a trypsin proteinase enzyme derived from North Atlantic codfish, (Gadus morhua) trade named Penzyme™. It is a byproduct of the Icelandic fishing industry and refined in a microfiltration, affinity chromatography process until a pure and humanly safe trypsin protease is produced.
In pilot tests, Penzyme has shown promise in various dermatological conditions (eczema, psoriasis etc.) as well as arthritic inflammatory discomfort, acne and wound healing, amongst others. Penzyme has now been used in two clinical studies on humans, one on UV radiation and the other on the wound-healing of pressure sores, both with encouraging results. Other controlled studies are being planned.
An unpublished randomised controlled clinical trial on wound-healing of pressure sores undertaken at the Faculty of Medicine, University of Malta determined that Penzim (AQUABALM) was found to be significantly more effective than conventional treatment. Results of clinical trials from Italy are positive for UV radiation burns and erythema. Several small studies have been undertaken in Iceland with encouraging results.
AQUABALM is the new brand name for the Icelandic product known as Penzim. The Icelandic company Zymetech is proposing to undertake clinical trials in two dermatological conditions to achieve a full product license.
AQUABALM is presented as a cosmetic or cosmeceutical product, meaning it has enhanced cosmetic properties. Ecobrands follows the regulations laid down by the Medicines and Healthcare Products Regulatory Agency (MHRA) and its packaging product descriptions are compliant with the guidelines. However, from the professional health perspective, it means that no references can be made to successful medical trials or any medical claims made about the AQUABALM product on the packaging.
North Atlantic codfish digest their food in an environment of very low sea temperatures; their digestive systems are equipped with enzymes adapted to function accordingly. When subjected to room temperature trypsin enzymes becomes 'super-active' and speed up chemical and biological reaction on the skin. Since it is cold-active, it is also heat-sensitive, and therefore short-lived outside the protection of the AQUABALM formulations. The refined trypsin enzyme is supported in an inert plant sourced glycerin which will not destroy it and is held in a perfectly balanced ph7 solution.
AQUABALM can be used for many conditions as well as cosmetic and beauty treatments. Its unique characteristic is trypsin's natural ability to cleave concentrations of pathological proteins from the surface cell membrane permitting leukocyte activity to remove damaged cells. Thus stimulating the removal of virus-infected cells, bacteria, fungi, various pathogens and assisting immune system defences.
For the ethically minded AQUABALM is artificial preservative free; no paraben, silicon, petroleum, PEG's or PPG's nor does it contain chemical additives, salt, sugar, solvents or fillers. No adverse reactions or allergies have been reported since the product has been available to the public since 1999. It is safe for use on children, during pregnancy and suitable for all types of skin.
Research at the University of Iceland established that the Penzyme technology developed from cod trypsin and chymotrypsin enzymes effectively remove or inactivate certain cell-surface adhesion molecules, bacterial enterotoxins, cytokines, inflammatory mediators and matrix metalloproteinases (MMPs) such as CD4, CD8, CD54 (ICAM-1), CD31, CD62L, CD102 (ICAM-2), CD11a/CD18, TNF-alfa, IL-1, and MMP-9, without affecting the cell viability. This adhesion site cleavage or inactivation phenomenon of cytokines, inflammatory mediators and matrix metalloproteinases is believed to provide at least a partial explanation for the effectiveness of cod trypsins and chymotrypsins against many of the indications against which they are effective. Thus, TNF-alpha is implicated in arthritis, psoriasis and inflammation (See Cytokines, Eds. Mire-Slui and Thrope, Academic press, 1998, p 350).
AQUABALM ointment has been shown to improve the wellbeing and comfort of people with the following conditions:
Eczema (including atopic eczema, seborrhoeic dermatitis and contact dermatitis).
Dry or chapped skin.
Warts and calluses.
Wound healing e.g. burns, erythema and cuts.
Musculoskeletal sprains e.g. tennis elbow, golfer's elbow, and various sports related injuries.
Muscle spasms and rejuvenating tired or sore muscles.
Osteoarthritis and rheumatoid arthritis.
To help keep the upper respiratory tract moist AQUABALM may be sprayed in the mouth.
AQUABALM is available in two forms: Gel and Spray. Both forms are equivalent in activity against all conditions.
The spray is recommended for use on larger areas of the body.
The gel is considered feasible for more local applications.
However the choice between gel and spray is primarily a question of individual preference.
A STUDY on the treatment of eczema, dermatitis and other skin conditions with Penzyme 100 gel (similar to the AQUABALM formula)
Eighteen patients suffering from eczema, dermatitis and various other skin conditions were treated with the cod trypsin hydrogel ointment Penzyme 100. The enzyme gel was applied once per day (occasionally twice), usually in the evening before retiring to bed. The gel was applied as a thin layer or film. Drying occurred after about 5-10 minutes. A higher amount may be applied in severe cases. This drying can be accelerated by the use of an air blowing device such as a hair dryer.
All these patients experienced relief from symptoms within one week, most of them in 2 to 4 days. Some of the patients (Nos. 40,41, 48, 66, 50, 20, 46, 87, 97, 100) had been able to discontinue treatment, without needing to recommence Penzyme 100 application, but others kept symptoms under control with constant or intermittent use of the product. The results are summarised in the following table:
Disclaimer: Statements made by Aquabalm have not been evaluated by the US FDA. Aquabalm is not intended to diagnose, treat, cure or prevent any illness or disease. Consult with your physician for diagnosis or treatment. The information presented on this site is not presented with the intention of diagnosing any disease or condition or prescribing any treatment. It is offered as information only, for use in the maintenance and promotion of good health in cooperation with a licensed medical practitioner.